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October 19, 2025Brain CommunicationsOpen Access

Comprehensive metabolomics profiling reveals novel biomarkers and pathways for early detection of Alzheimer’s disease

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Authors

PTPrabhakar TiwariAGAnu GuptaMKMeenakshi Kaushik

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Overview

Profiling identifies distinct metabolites and biomarkers in Alzheimer’s disease, suggesting pathways for early detection.

Key Points

  • Distinct metabolic profiles linked to alzheimer's disease were observed, revealing potential biomarkers for early detection.
  • Principal component analysis highlighted 75 altered metabolites, with octadecanedicarboxylic acid showing an AUC of 0.917 as a key marker.
  • Metabolomics techniques and biomarker analysis were utilized to assess cognitive decline and identify metabolic alterations in patients.
  • Integrated findings emphasize neuroinflammation and oxidative stress pathways, supporting future validation in larger cohorts.

Cite This Study

Tiwari et al. (2025) studied this question.

synapsesocial.com/papers/68f43eeb854d1061a58aba8dhttps://doi.org/10.1093/braincomms/fcaf410
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