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September 17, 2025

Evaluation of intravoxel incoherent motion (IVIM) to detect bone marrow ischemia and perfusion in a piglet model of Legg-Calvé-Perthes disease

Key Points

IVIM effectively detected reduced perfusion in regions with ischemia compared to perfused areas.
The study used 3T MRI data from four piglets with varying levels of femoral head ischemia.
Gadolinium-enhanced MRI identified ischemic regions, serving as a comparative standard for IVIM analysis.
The findings indicate IVIM's potential to improve diagnosis in children with conditions like Legg-Calvé-Perthes disease.

Abstract

Motivation: A safe, non-contrast-enhanced method to detect bone marrow ischemia and perfusion is needed for imaging children with ischemic bone disorders such as Legg-Calvé-Perthes disease (LCPD). Goal(s): To determine if intravoxel incoherent motion (IVIM) is sensitive in detecting localized regions of bone marrow ischemia and perfusion within the femoral head. Approach: 3T MRI data from N=4 piglets with partial (25-75%) femoral head ischemia were retrospectively analyzed to evaluate and compare IVIM parameters in ischemic vs. perfused regions of the femoral heads as identified by gadolinium contrast-enhanced MRI (CE-MRI). Results: IVIM detected decreased perfusion parameters in the ischemic vs. perfused regions identified by CE-MRI. Impact: Our results provide additional evidence that IVIM can serve as a non-contrast-enhanced alternative to gadolinium CE-MRI in detecting regions of bone marrow ischemia and perfusion, with potential benefit for pediatric patients with ischemic bone disorders including LCPD.

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