Intraoperative Opioid-Free Anesthesia with Dexmedetomidine and Esketamine Versus Conventional General Anesthesia in Laparoscopic Cholecystectomy at 3,600 m: A Randomized Trial on Hemodynamic Stability and Postoperative Recovery

Key Points

• Intraoperative opioid-free anesthesia improved hemodynamic stability during laparoscopic cholecystectomy.
• The trial utilized an intravenous combination of dexmedetomidine and esketamine with conventional techniques.
• Patients experienced better postoperative recovery metrics compared to those under general anesthesia.
• Findings suggest a potential shift in practice toward opioid-free anesthesia for similar surgical procedures.