Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Key Points

• This method accelerates drug discovery by enabling biological screening directly from crude reaction mixtures.
• The miniaturized Direct-to-Biology approach significantly eliminates purification steps, improving efficiency.
• Rapid development of sEH PROTACs showcases the potential of click chemistry in modern pharmacology.
• The findings highlight how streamlined processes can transform traditional drug development methodologies.