Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Q: What type of study is this?

This is a Experimental Study study.

Julia Schoenfeld; Nick Liebisch; Steffen Brunst; Lilia Weizel; Stefan Knapp; Aimo Kannt; Ewgenij Proschak; Kerstin Hiesinger

doi:10.1039/d5cc03325j

January 1, 2025Chemical CommunicationsOpen Access

Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

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Key Points

This method accelerates drug discovery by enabling biological screening directly from crude reaction mixtures.
The miniaturized Direct-to-Biology approach significantly eliminates purification steps, improving efficiency.
Rapid development of sEH PROTACs showcases the potential of click chemistry in modern pharmacology.
The findings highlight how streamlined processes can transform traditional drug development methodologies.

Implication

This innovative approach enhances biological screening for sEH PROTACs, suggesting faster drug discovery.

Abstract

The Direct-to-Biology (D2B) approach enables biological screening of crude reaction mixtures, eliminating the need for purification steps and thereby accelerating drug discovery. In this study, we developed a miniaturized D2B...

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Cite This Study

Schoenfeld et al. (2025) studied this question.

synapsesocial.com/papers/68e585d0b1e78cc4e5f4643e https://doi.org/10.1039/d5cc03325j

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Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Key Points

Implication

Abstract

Discussion

Cite This Study

Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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