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Abstract A multicomponent cascade cyclization reaction using aryl methyl ketones, aryl amines, and enaminamide reagents to construct 3‐hydroxy‐1 H ‐pyrrolo3,4‐ b quinolin‐1‐one skeleton with good substrate compatibility (50 examples) has been reported. The one‐pot, metal‐free process formed two C−C bonds, two C−N bonds, and a tetrasubstituted carbon stereocenter containing a hydroxyl group. The reaction enabled modified transformation of drug molecules and derivatization of products.
Shen et al. (Tue,) studied this question.
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