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PARP1 inhibition prevents ribosome biogenesis and decreases protein translation. Treatment with niraparib significantly decreases rRNA subunit (18S) production in endometrial (A) and ovarian (B) cancer cells as assayed by qPCR. Each bar represents the mean + SEM; n = 3. Bars marked with asterisks are significantly different; Student t test; *, P P P P C) and ovarian (D) cancer cells as assayed by Western blotting. E and F, Quantification of puromycin incorporation assay from C and D, respectively. Each bar represents the mean + SEM; n = 3. Bars marked with asterisks are significantly different; Student t test; *, P P P P
Aljardali et al. (Thu,) studied this question.