Summary: Pancreatic cancer is known as the “king of cancers” due to its aggressive progression and poor prognosis. Wang, Wang, Zhang, and colleagues develop a promising liquid biopsy approach that uses features derived from a single run of low-pass whole-genome cell-free DNA sequencing to predict pancreatic cancer years before diagnosis in a large asymptomatic high-risk cohort, markedly outperforming existing biomarkers and projecting survival gains. See related article by Wang et al., p. 66
Tsui et al. (Mon,) studied this question.