DNA methylation-mediated silencing of MEOX1 promotes glycolysis and immune evasion in colorectal cancer cells through inhibition of GLP2R transcription | Synapse
February 2, 2026Open Access
DNA methylation-mediated silencing of MEOX1 promotes glycolysis and immune evasion in colorectal cancer cells through inhibition of GLP2R transcription
Key Points
The research aims to explore how DNA methylation impacts MEOX1 and GLP2R transcription in colorectal cancer cells.
Analyzed the role of DNA methylation in MEOX1 expression.
Examined the effects on GLP2R transcription.
Investigated impacts on glycolysis and Hippo signaling.
DNA hypermethylation inhibited MEOX1 expression.
This inhibition decreased GLP2R transcription.
Activated glycolysis was linked to increased colorectal cancer growth and immune evasion.
Abstract
DNA hypermethylation blocked MEOX1-mediated GLP2R transcription, which activated glycolysis in CRC cells by inhibiting Hippo signaling, leading to CRC growth, metastasis, and immune evasion.