Demonstrates how DNA methylation affects glycolysis and immune evasion in colorectal cancer, indicating a potential treatment target.
DNA hypermethylation blocked MEOX1-mediated GLP2R transcription, which activated glycolysis in CRC cells by inhibiting Hippo signaling, leading to CRC growth, metastasis, and immune evasion.
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Liang et al. (2026) studied this question.
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