What question did this study set out to answer?

This study aims to investigate the role of ELMO1 in macrophage infiltration and anti-PD-1 efficacy in MSI-H colorectal cancer.

June 21, 2026Gastroenterology reportOpen Access

Targeting engulfment and cell motility 1 protein methylation attenuates M2 macrophage infiltration and boosts anti-PD-1 efficacy in colorectal cancer

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Randomized trial demonstrates enhanced anti-PD-1 efficacy in MSI-H CRC by targeting ELMO1 methylation.

This study aims to investigate the role of ELMO1 in macrophage infiltration and anti-PD-1 efficacy in MSI-H colorectal cancer.
Evaluated ELMO1 expression and macrophage infiltration using qRT-PCR and immunohistochemistry.
Used XTT assays and foci formation assays to assess tumor viability.
Analyzed macrophage phenotypes by flow cytometry and RNA sequencing.
ELMO1 was overexpressed in MSI-H CRC and linked to poor clinical outcomes.
Inhibition of PRMT5 reduced ELMO1 methylation, decreasing M2 macrophage infiltration and inhibiting tumor growth.
Targeting ELMO1 significantly improved responsiveness to anti-PD-1 therapy in ELMO1-overexpressing MSI-H CRC.

Li et al. (2026) studied this question.

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