Glymphatic System Dysfunction and Diffusion Tensor Imaging Along the Perivascular Space in Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Key Points

• To assess the relationship between glymphatic dysfunction and diffusion tensor imaging (DTI) parameters in traumatic brain injury (TBI).
• Conducted a systematic review and meta-analysis
• Analyzed DTI-ALPS values in TBI
• Evaluated long-term effects of TBI on glymphatic function
• Found significantly reduced DTI-ALPS values in TBI
• Noted more severe deterioration of values over the long term
• Highlighted the need for standardized protocols to establish clinical utility