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This research investigates the effectiveness of clinical and dermoscopic evaluations in monitoring treatment response to sonidegib for basal cell carcinoma.

February 25, 2026Open Access

Pathological Insights into the Limitations of Clinical and Dermoscopic Evaluations in Monitoring Sonidegib Treatment Response for Locally Advanced Basal Cell Carcinoma: A Real-World Study

Key Points

This research investigates the effectiveness of clinical and dermoscopic evaluations in monitoring treatment response to sonidegib for basal cell carcinoma.
Analyzed a real-world cohort of patients with locally advanced basal cell carcinoma
Evaluated clinical and dermoscopic assessments post-treatment
Identified false positives in evaluations due to treatment-related changes
Sonidegib produced a significant clinical response and was safe for patients
Clinical and dermoscopic evaluations had considerable false positive rates
Pathological biopsy was necessary for validating tumor clearance

Abstract

In this real-world Chinese laBCC cohort, sonidegib produced a clinically meaningful response with a favorable safety profile. However, clinical and dermoscopic assessments showed substantial false positives due to posttreatment changes; pathological biopsy remains essential to confirm tumor clearance. Advanced noninvasive imaging (e.g., reflectance confocal microscopy) may further improve monitoring. Prospective studies with longer follow-up are warranted.

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