Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease

Key Points

• This research aims to develop and evaluate new compounds that can inhibit both AChE and MAO-B enzymes to treat Alzheimer's disease effectively.
• Synthesis of 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives
• Biological evaluation of synthesized compounds as dual inhibitors
• Assessment of efficacy against AChE and MAO-B enzymes
• Several derivatives exhibited significant inhibition of AChE and MAO-B.
• New compounds showed potential to improve therapeutic outcomes for Alzheimer’s disease.
• Results indicate a multi-target approach may be effective in AD treatment.