What question did this study set out to answer?

To compare the effectiveness of chlorhexidine and povidone-iodine in preventing surgical site infections (SSIs).

March 1, 2026

Comparing the efficacy of chlorhexidine and povidone-iodine for surgical site disinfection: a systematic review and meta-analysis from randomized controlled trials.

Key Points

To compare the effectiveness of chlorhexidine and povidone-iodine in preventing surgical site infections (SSIs).
Conducted a systematic review and meta-analysis
Included randomized controlled trials
Compared outcomes of chlorhexidine and povidone-iodine for SSI prevention
Chlorhexidine showed statistical superiority over povidone-iodine in preventing overall and superficial SSIs
No significant differences found in deep or organ/space SSIs
Secondary outcomes like hospital stay, readmission, and reoperation rates were not significantly different

Abstract

CH demonstrates statistical superiority over PVI in preventing overall and superficial SSI, though the absolute clinical benefit is modest. No significant differences were observed for deep or organ/space SSI, nor for secondary outcomes including hospital length of stay, readmission, or reoperation rates.

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