Apolipoprotein A-1 and HDL cholesterol had equally strong inverse associations with ASCVD risk (HR 0.85 per 1 SD increase, p<0.0001) in adults without prior CVD over 11 years.
Observational (n=291,995)
Yes
Are ApoA-1 and HDL-C equivalent markers of ASCVD risk?
ApoA-1 and HDL-C show equivalent strength of association with ASCVD risk, independent of concurrent triglyceride levels.
Effect estimate: HR 0.85 per 1 SD increase for both apoA-1 and HDL-C (95% CI HDL-C: 0.83-0.87; apoA-1: 0.83-0.86)
p-value: p=<0.0001
HDL-C and apoA-1 have associations of equivalent strength with ASCVD risk, with significant interaction modifying the effect of one by the other. Upon decomposition, apoA-I retained more of the effect of HDL-C as compared with log-triglycerides. While only observational, the results are consistent with the relation of HDL to risk not being determined by the concurrent level of triglyceride.
BİLGİÇ et al. (Sun,) conducted a observational in Adults without prior cardiovascular disease or lipid-lowering therapy with available baseline lipid profile data (n=291,995). Apolipoprotein A-1 (apoA-1) measurement compared to HDL cholesterol (HDL-C) measurement vs. Comparative observational assessment of apoA-1 vs HDL-C as markers of ASCVD risk was evaluated on Incident atherosclerotic cardiovascular disease (ASCVD) events (HR 0.85 per 1 SD increase for both apoA-1 and HDL-C, 95% CI HDL-C: 0.83-0.87; apoA-1: 0.83-0.86, p=<0.0001). Apolipoprotein A-1 and HDL cholesterol had equally strong inverse associations with ASCVD risk (HR 0.85 per 1 SD increase, p<0.0001) in adults without prior CVD over 11 years.