Apolipoprotein A-1 and HDL cholesterol had equally strong inverse associations with ASCVD risk (HR 0.85 per 1 SD increase, p<0.0001) in adults without prior CVD over 11 years.
Observational (n=291,995)
Yes
Are ApoA-1 and HDL-C equivalent markers of ASCVD risk?
ApoA-1 and HDL-C show equivalent strength of association with ASCVD risk, independent of concurrent triglyceride levels.
Effect estimate: HR 0.85 per 1 SD increase for both apoA-1 and HDL-C (95% CI HDL-C: 0.83-0.87; apoA-1: 0.83-0.86)
p-value: p=<0.0001
HDL-C and apoA-1 have associations of equivalent strength with ASCVD risk, with significant interaction modifying the effect of one by the other. Upon decomposition, apoA-I retained more of the effect of HDL-C as compared with log-triglycerides. While only observational, the results are consistent with the relation of HDL to risk not being determined by the concurrent level of triglyceride.
BİLGİÇ et al. (2026) conducted an observational in Adults without prior cardiovascular disease or lipid-lowering therapy with available baseline lipid profile data (n=291,995). Apolipoprotein A-1 (apoA-1) measurement compared to HDL cholesterol (HDL-C) measurement vs. Comparative observational assessment of apoA-1 vs HDL-C as markers of ASCVD risk was evaluated on Incident atherosclerotic cardiovascular disease (ASCVD) events (HR 0.85 per 1 SD increase for both apoA-1 and HDL-C, 95% CI HDL-C: 0.83-0.87; apoA-1: 0.83-0.86, p=<0.0001). Apolipoprotein A-1 and HDL cholesterol had equally strong inverse associations with ASCVD risk (HR 0.85 per 1 SD increase, p<0.0001) in adults without prior CVD over 11 years.