March 3, 2026Open Access

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

Key Points

Sustained antidepressant use is influenced by phenotypic factors, highlighting their significance.
The study found treatment complexity associated with specific polygenic scores (PGSs) for certain traits.
Observational analysis across different treatment groups indicates a limited correlation with sustained-use outcomes.
Identifying phenotypic associations may help inform targeted interventions for difficult-to-treat depression.

Abstract

This study found that phenotypic factors were associated with sustained antidepressant use and treatment complexity. PGSs for traits studied were associated with treatment complexity but showed little association with sustained-use 360 groups. These findings support further research to guide treatment selection and to identify patients at risk of difficult-to-treat depression, informing precision psychiatry and early intervention in MDD.

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

Key Points

Abstract

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