March 3, 2026Open Access

Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus

Key Points

Increased interferon levels are linked to distinct clinical traits and immune responses in systemic lupus erythematosus.
A significant correlation was found between IFNα levels and disease activity, measured by the SLEDAI score.
Assessment of IFN pathways at both protein and gene expression levels provides insights into SLE's clinical heterogeneity.
The identification of biomarkers may enable better disease monitoring and personalized treatment strategies for patients.

Abstract

All three IFN pathways were elevated in SLE. Correlation of IFNα levels and IFN score with SLEDAI suggested their potential as possible biomarker for monitoring disease activity. Association of IFNλ4 with IFN score suggested their possible role in IFN pathway activation.By assessing IFNs at both protein and transcriptional levels, present study provided comprehensive insight into IFN pathway dynamics and IFN-driven heterogeneity in SLE.

Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus

Key Points

Abstract

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