March 3, 2026Open Access

Advancing CAR-T therapy in prostate cancer: overcoming the tumor microenvironment and enhancing efficacy

Key Points

Innovations in CAR-T therapy aim to enhance its efficacy against prostate cancer, overcoming tumor microenvironment challenges.
Recent advances include improved CAR design and novel combination strategies that show promise in treatment effectiveness.
This review highlights CAR-T targets and various engineering strategies that can lead to better treatment outcomes in prostate cancer.
Addressing the tumor microenvironment remains crucial for achieving durable responses in advanced prostate cancer cases.

Abstract

CAR-T therapy for prostate cancer is a rapidly advancing field. This review provides an updated perspective on CAR-T targets, engineering strategies, and combination approaches in PCa. Ongoing innovations in CAR design and therapeutic combinations offer the potential to develop more effective and durable CAR-T treatments for advanced prostate cancer.

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Authors

Zhongze Zhou

Anhui University

Yongfeng Lao

Kun Zhao

Shihezi University

Journals

SHILAP Revista de lepidopterología

Frontiers in Oncology

Actions

Institutions

Lanzhou University

Lanzhou University Second Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Advancing CAR-T therapy in prostate cancer: overcoming the tumor microenvironment and enhancing efficacy

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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