The impact of weight loss on the physiological endotypes associated with obstructive sleep apnea

Key Points

• Improvements in apnea-hypopnea index (AHI) and airway physiology are significant with weight loss.
• Weight loss via metabolic bariatric surgery notably enhances upper airway collapsibility and loop gain.
• This analysis focuses on patients experiencing mild upper airway collapsibility and low loop gain to assess specific effects.
• Such findings indicate the need for targeted interventions in managing obstructive sleep apnea associated with weight issues.