Chitosan and dialdehyde starch as macromolecular platforms for sulfa azo dye/selenium nanocomposites: Synthesis, molecular modelling, and dual DNA gyrase–DHFR inhibition | Synapse
March 3, 2026
Chitosan and dialdehyde starch as macromolecular platforms for sulfa azo dye/selenium nanocomposites: Synthesis, molecular modelling, and dual DNA gyrase–DHFR inhibition
Key Points
Dual inhibition of DNA gyrase and dihydrofolate reductase was demonstrated, indicating a promising therapeutic strategy.
The synthesis of sulfa azo dye/selenium nanocomposites utilized chitosan and dialdehyde starch as macromolecular platforms.
Molecular modeling provided insights into the interaction mechanisms of the nanocomposites with target enzymes.
Using these macromolecular platforms may enhance drug delivery and efficacy in therapeutic applications.