RNA-binding protein TARDBP enhances NPTX1 stability to induce neuronal injury and diabetic cognitive impairment

Key Points

• Neuronal injury is associated with increased TARDBP levels, leading to cognitive impairment.
• Changes in NPTX1 stability affect neuronal health and cognitive function in diabetes.
• The molecular pathway involves the interaction between TARDBP and NPTX1, impacting neuronal integrity.
• Understanding this pathway may suggest therapeutic targets for diabetic cognitive dysfunction.