Prolonged Renal Dysfunction in Patients Undergoing Chemotherapy for Locally Advanced Esophageal Cancer: Treatment Implications and Risk Factors.

Key Points

• The study aims to identify risk factors for prolonged renal dysfunction during chemotherapy in esophageal cancer patients.
• Analyzed serum creatinine levels before chemotherapy.
• Monitored urine volume on day 1 of the first chemotherapy cycle.
• Investigated the impact of renal dysfunction on the dose intensity of cisplatin.
• Prolonged renal dysfunction was linked to lower relative dose intensity of cisplatin.
• Pre-chemotherapy serum creatinine levels were identified as a critical risk factor.
• Urine volume on the first day of treatment also correlated with renal outcomes.