Immediate Administration of Mineralocorticoid Receptor Antagonist Spironolactone Prevents Post-Infarct Left Ventricular Remodeling Associated With Suppression of a Marker of Myocardial Collagen Synthesis in Patients With First Anterior Acute Myocardial Infarction
Does immediate administration of spironolactone combined with an ACE inhibitor prevent post-infarct left ventricular remodeling in patients with a first anterior acute myocardial infarction?
P
Population
Patients with first anterior acute myocardial infarction
I
Intervention
Immediate administration of mineralocorticoid receptor antagonist (spironolactone) combined with an ACE inhibitor
C
Comparator
ACE inhibitor alone
O
Outcome
Post-infarct left ventricular remodeling and suppression of a marker of myocardial collagen synthesissurrogate
Immediate administration of spironolactone on top of ACE inhibitors helps prevent adverse left ventricular remodeling following a first anterior acute myocardial infarction.
Abstract
These findings indicate that MRA combined with ACE inhibitor can prevent post-infarct LV remodeling better than ACE inhibitor alone in association with the suppression of a marker of collagen synthesis.
Immediate Administration of Mineralocorticoid Receptor Antagonist Spironolactone Prevents Post-Infarct Left Ventricular Remodeling Associated With Suppression of a Marker of Myocardial Collagen Synthesis in Patients With First Anterior Acute Myocardial Infarction | Synapse
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