Does immediate administration of spironolactone combined with an ACE inhibitor prevent post-infarct left ventricular remodeling in patients with a first anterior acute myocardial infarction?
Immediate administration of spironolactone on top of ACE inhibitors helps prevent adverse left ventricular remodeling following a first anterior acute myocardial infarction.
These findings indicate that MRA combined with ACE inhibitor can prevent post-infarct LV remodeling better than ACE inhibitor alone in association with the suppression of a marker of collagen synthesis.
Hayashi et al. (2003) studied this question.
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