A Responsive Co(II) 19 F PARAShift Probe: Activation of Fermi Contact Interactions Triggered by pH-dependent Coordination Changes | Synapse
March 12, 2026Open Access
A Responsive Co(II) 19 F PARAShift Probe: Activation of Fermi Contact Interactions Triggered by pH-dependent Coordination Changes
Key Points
This research aims to develop a novel 19F MR imaging probe that responds to pH changes.
Designed a novel 19F imaging probe called CoNO2ASF5.
Measured 19F chemical shift changes in response to varying pH levels.
Monitored over 30 ppm chemical shift for physiologically relevant pH changes.
Achieved a 19F chemical shift change of over 30 ppm with pH variations.
Demonstrated activation of Fermi contact interactions due to coordination changes associated with pH.
Abstract
We report a novel 19 F MR imaging probe CoNO2ASF 5 exhibiting a large 19 F chemical shift change of over 30 ppm in response to physiologically relevant pH changes. This shift occurs...