A Responsive Co(II) ¹⁹ F PARAShift Probe: Activation of Fermi Contact Interactions Triggered by pH-dependent Coordination Changes

Q: What does this research mean for the field?

The CoNO2ASF 5 probe exhibits a large 19F chemical shift change of over 30 ppm in response to physiologically relevant pH changes, enabling responsive MR imaging. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kathleen M. Scott; Rahul T. Kadakia; Jackson A. Reyna; Emily L. Que; Christopher D. Hastings; Georgia Barone; Jin Xiong; Yisong Guo

doi:10.1039/d6cc00957c

January 1, 2026Chemical CommunicationsOpen Access

A Responsive Co(II) ¹⁹ F PARAShift Probe: Activation of Fermi Contact Interactions Triggered by pH-dependent Coordination Changes

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Key Points

This research aims to develop a novel 19F MR imaging probe that responds to pH changes.
Designed a novel 19F imaging probe called CoNO2ASF5.
Measured 19F chemical shift changes in response to varying pH levels.
Monitored over 30 ppm chemical shift for physiologically relevant pH changes.
Achieved a 19F chemical shift change of over 30 ppm with pH variations.
Demonstrated activation of Fermi contact interactions due to coordination changes associated with pH.

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Implication

A novel probe demonstrates significant pH-dependent imaging changes, indicating its potential in biomedical applications.

Abstract

We report a novel 19 F MR imaging probe CoNO2ASF 5 exhibiting a large 19 F chemical shift change of over 30 ppm in response to physiologically relevant pH changes. This shift occurs...

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Cite This Study

Scott et al. (2026) studied this question.

synapsesocial.com/papers/69b2585696eeacc4fcec7d32 https://doi.org/10.1039/d6cc00957c

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A Responsive Co(II) ¹⁹ F PARAShift Probe: Activation of Fermi Contact Interactions Triggered by pH-dependent Coordination Changes

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Implication

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Cite This Study

A Responsive Co(II) ¹⁹ F PARAShift Probe: Activation of Fermi Contact Interactions Triggered by pH-dependent Coordination Changes

Key Points

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Implication

Abstract

Discussion

Cite This Study

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