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March 12, 2026

Study on the Function and Mechanism of Neutrophil Extracellular Traps in Regulating Necroptosis Following Traumatic Brain Injury.

Key Points

The research aims to explore the role of neutrophil extracellular traps in regulating necroptosis following traumatic brain injury.
Examined the impact of NETs on secondary brain injury after TBI
Investigated the activation of the necroptosis pathway
Assessed the neuroprotective effects of inhibiting NETs
NETs exacerbate secondary brain injury in TBI
Inhibition of NETs shows neuroprotective effects
Targeting NETs presents a potential therapeutic strategy for TBI patients

Abstract

NETs exacerbate TBI-induced secondary brain injury partially by activating the necroptosis pathway. Inhibition of NETs exerts neuroprotective effects. Targeting NETs may serve as a promising therapeutic strategy to improve prognosis in TBI patients.

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Authors

Ao Li

Anhui Medical University

Tian-Wei Pei

Xiangshan County First People's Hospital

Hao Qi

Jiangnan University

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Jiangnan University

Anhui Medical University

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Study on the Function and Mechanism of Neutrophil Extracellular Traps in Regulating Necroptosis Following Traumatic Brain Injury.

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Abstract

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Authors

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