What does this research mean for the field?

circMELK promotes nasopharyngeal carcinoma progression through an m6A-dependent ceRNA regulatory loop involving YTHDF1, miR-4775, and HMGA2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates how m⁶A-modified circMELK influences nasopharyngeal carcinoma (NPC) progression through a regulatory mechanism.

March 14, 2026Molecular Immunology0 citationsOpen Access

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m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop

QYQiang YiGannan Medical University KZKui ZhongJiangsu University of Science and Technology ZCZheng ChenGannan Medical University

Key Points

This research investigates how m⁶A-modified circMELK influences nasopharyngeal carcinoma (NPC) progression through a regulatory mechanism.
Analyzed the role of circMELK in NPC progression
Examined the m6A modification and its influence on YTHDF1
Investigated the circMELK-miR-4775-HMGA2 feedback loop
circMELK promotes NPC progression through an m6A-dependent mechanism
YTHDF1 plays a significant role in this regulatory loop
Targeting this pathway could provide new therapeutic opportunities for NPC

Abstract

circMELK promotes NPC progression via a novel m6A-dependent ceRNA regulatory loop. Targeting this axis may offer new therapeutic opportunities.

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m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop

Key Points

Abstract

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