m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop

Q: What does this research mean for the field?

circMELK promotes nasopharyngeal carcinoma progression through an m6A-dependent ceRNA regulatory loop involving YTHDF1, miR-4775, and HMGA2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Qiang Yi; Kui Zhong; Zheng Chen; Xinting Ouyang; Weijian Zhu; Leifeng Liang; Jinghua Zhong

doi:10.1016/j.molimm.2026.03.002

March 10, 2026Molecular ImmunologyOpen Access

m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop

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Key Points

This research investigates how m⁶A-modified circMELK influences nasopharyngeal carcinoma (NPC) progression through a regulatory mechanism.
Analyzed the role of circMELK in NPC progression
Examined the m6A modification and its influence on YTHDF1
Investigated the circMELK-miR-4775-HMGA2 feedback loop
circMELK promotes NPC progression through an m6A-dependent mechanism
YTHDF1 plays a significant role in this regulatory loop
Targeting this pathway could provide new therapeutic opportunities for NPC

Implication

This research uncovers a feedback loop involving circMELK that influences cancer progression, suggesting novel treatment paths.

Abstract

circMELK promotes NPC progression via a novel m6A-dependent ceRNA regulatory loop. Targeting this axis may offer new therapeutic opportunities.

Discussion

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Cite This Study

Yi et al. (2026) studied this question.

synapsesocial.com/papers/69b4fa6fb39f7826a300b2b8 https://doi.org/10.1016/j.molimm.2026.03.002

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m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop

Key Points

Implication

Abstract

Discussion

Cite This Study

m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop

Key Points

Implication

Abstract

Discussion

Cite This Study

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