What question did this study set out to answer?

To evaluate the role of histopathology in KCNJ5-negative primary aldosteronism and its association with surgical outcomes.

March 15, 2026

KCNJ5 -Negative Primary Aldosteronism: Histopathology and Surgical Outcomes

Key Points

To evaluate the role of histopathology in KCNJ5-negative primary aldosteronism and its association with surgical outcomes.
Analysis of histopathological features in KCNJ5-negative uPA cases
Comparison of clinical success rates based on histopathologic classification
Nearly half of KCNJ5-negative uPA cases show nonclassical adrenal histopathology
Lower complete clinical success rates correlate with nonclassical histopathology

Abstract

Nearly half of KCNJ5-negative uPA cases exhibit nonclassical adrenal histopathology, which is associated with significantly lower complete clinical success rates. These findings underscore the prognostic value of histopathologic classification in KCNJ5-negative uPA and support integrating histology and genetics to improve patient management.

KCNJ5 -Negative Primary Aldosteronism: Histopathology and Surgical Outcomes

Key Points

Abstract

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