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KCNJ5 -Negative Primary Aldosteronism: Histopathology and Surgical Outcomes | Synapse

March 15, 2026

KCNJ5 -Negative Primary Aldosteronism: Histopathology and Surgical Outcomes

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Key Points

To evaluate the role of histopathology in KCNJ5-negative primary aldosteronism and its association with surgical outcomes.
Analysis of histopathological features in KCNJ5-negative uPA cases
Comparison of clinical success rates based on histopathologic classification
Nearly half of KCNJ5-negative uPA cases show nonclassical adrenal histopathology
Lower complete clinical success rates correlate with nonclassical histopathology

Abstract

Nearly half of KCNJ5-negative uPA cases exhibit nonclassical adrenal histopathology, which is associated with significantly lower complete clinical success rates. These findings underscore the prognostic value of histopathologic classification in KCNJ5-negative uPA and support integrating histology and genetics to improve patient management.

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Authors

C

Che‐Hsiung Wu

Tzu Chi University

K

Kang-Yung Peng

Y

Ya‐Wen Yang

National Taiwan University Hospital

Journals

Hypertension

Actions

Institutions

National Taiwan University

National Taiwan University Hospital

Chang Gung University

References and Citations

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Cite this study

Wu et al. (Fri,) studied this question.

synapsesocial.com/papers/69b6069b83145bc643d1ca09 — DOI: https://doi.org/10.1161/hypertensionaha.125.26266