Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma

Key Points

• The central goal is to evaluate the effectiveness of oncostatin-M ligand-based CAR-T cells against osteosarcoma.
• Leveraged human ligand-based OSM CAR-T cells
• Conducted in vitro experiments
• Utilized xenograft models
• Simulated metastatic disease models
• OSM CAR-T cells exhibited anti-tumor effects across various osteosarcoma cell lines
• Demonstrated significant activity in patient-derived samples
• Supported the potential for OSM-CAR-T cells as a novel therapeutic option