DS96432529 enhances osteogenic differentiation and mitigates inflammatory damage in periodontal ligament stem cells involving mitophagy-related processes

Key Points

• The study aims to investigate how DS96432529 influences osteogenic differentiation and inflammatory damage in periodontal ligament stem cells (PDLSCs).
• Evaluated the osteogenic potential of PDLSCs treated with DS96432529
• Assessed mitophagy-related processes
• Analyzed the RIG-I-mediated RLR signaling pathway
• DS96432529 significantly enhances the osteogenic differentiation of PDLSCs
• It reduces inflammatory damage associated with osteogenesis
• Increased activity of mitophagy-related processes was observed

Abstract