Research demonstrates enhanced osteogenesis in periodontal ligament stem cells, suggesting therapeutic potential for periodontitis-induced bone loss.
DS enhances the osteogenic potential of PDLSCs in association with the activation of mitophagy-related processes. It mitigates inflammation-impaired osteogenesis, potentially via modulation of the RIG-I-mediated RLR signaling pathway, in association with increased mitophagy-related activity. DS represents a potent therapeutic small molecule for ameliorating periodontitis-induced bone loss.
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He et al. (2026) studied this question.
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