Does low-dose oral anticoagulation with INR self-management increase the risk of thrombo-embolic events compared to conventional dose INR self-management in patients with mechanical heart valve prostheses?
Low-dose INR self-management in patients with mechanical heart valves does not increase thrombo-embolic risk compared to conventional dosing, though bleeding remains the predominant risk.
Data demonstrate that low-dose INR self-management does not increase the risk of thrombo-embolic events compared with conventional dose INR self-management. Even in patients with low INR target range, the risk of bleeding events is still higher than the risk of thrombo-embolism.
Koertke et al. (Fri,) studied this question.
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