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September 7, 2007European Heart JournalOpen Access

Low-dose oral anticoagulation in patients with mechanical heart valve prostheses: final report from the early self-management anticoagulation trial II

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Why the study?

Does low-dose oral anticoagulation with INR self-management increase the risk of thrombo-embolic events compared to conventional dose INR self-management in patients with mechanical heart valve prostheses?

Population

Patients with mechanical heart valve prostheses

Comparison

Low-dose oral anticoagulation with INR… vs Conventional dose oral anticoagulation with INR…

Design

RCT

Authors

HKHeinrich KoertkeHeart and Diabetes Center North Rhine-WestphaliaAZArmin ZittermannHeart and Diabetes Center North Rhine-WestphaliaGTGero TenderichCardiovascular Center Frankfurt

Discussion

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Implication

Supports low-dose INR self-management in mechanical valves; extends RCT evidence for reduced-intensity targets.

Structured PICO

Does low-dose oral anticoagulation with INR self-management increase the risk of thrombo-embolic events compared to conventional dose INR self-management in patients with mechanical heart valve prostheses?

P
Population
Patients with mechanical heart valve prostheses
I
Intervention
Low-dose oral anticoagulation with INR self-management
C
Comparator
Conventional dose oral anticoagulation with INR self-management
O
Outcome
Thrombo-embolic eventshard clinical

Low-dose INR self-management in patients with mechanical heart valves does not increase thrombo-embolic risk compared to conventional dosing, though bleeding remains the predominant risk.

Cite This Study

Koertke et al. (2007) studied this question.

synapsesocial.com/papers/69c1aeceaa580801bf53b3f7https://doi.org/10.1093/eurheartj/ehm391

Topics

Anticoagulation in AF
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1INR Self-Management Permits Lower Anticoagulation Levels After Mechanical Heart Valve Replacement2003 · 101 citations
  2. 2Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy1984 · 106 citations
  3. 3Care of Patients Receiving Long-Term Anticoagulant Therapy2003 · 250 citations