Enantioselective Construction of Chiral Quinoline Scaffold via a Michael Addition/O-Alkylation Sequence

Key Points

• This research develops a method for creating chiral dihydrofuroquinoline scaffolds through a specific chemical reaction, highlighting enantioselectivity.
• Conducted a cascade reaction using hydroxyquinolines and chloronitroalkenes.
• Examined various conditions to achieve high enantioselectivity.
• Modified hydroxylcamptothecin as part of the synthesis.
• Constructed chiral dihydrofuroquinoline scaffolds with high enantioselectivity.
• Demonstrated direct modification capability of hydroxylcamptothecin.
• Noted potential anti-tumour activity of the synthesized compounds.