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March 26, 2026

Weight Loss Outcomes Between GLP ‐1 Receptor Agonists and Bariatric Surgery in Adults With Obesity: A Systematic Review, Meta‐Analysis and Meta‐Regression

Key Points

This research aims to compare weight loss outcomes between GLP-1 receptor agonists and bariatric surgery in adults with obesity.
Conducted a systematic review and meta-analysis
Included multi-year follow-up data
Performed meta-regression analysis
Bariatric surgery was associated with greater weight loss compared to GLP-1 receptor agonists
Sustained reductions in BMI and glycaemic indices observed over several years
Similar effects on serum lipids and blood pressure noted in both interventions

Abstract

Although substantial heterogeneity was present, BS was associated with greater and sustained reductions observed over multi-year follow up in weight, BMI and glycaemic indices compared to GLP-1 RAs, with similar effects on serum lipids and blood pressure, supporting its use in appropriately selected adults with obesity.

Weight Loss Outcomes Between GLP ‐1 Receptor Agonists and Bariatric Surgery in Adults With Obesity: A Systematic Review, Meta‐Analysis and Meta‐Regression

Key Points

Abstract

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