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March 26, 2026Diabetes Obesity and Metabolism2 citations

Weight Loss Outcomes Between GLP ‐1 Receptor Agonists and Bariatric Surgery in Adults With Obesity: A Systematic Review, Meta‐Analysis and Meta‐Regression

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MTMohammad TahirDow University of Health SciencesMMMehreen MeghaniWayne State UniversityMUMuhammad Salik UddinWayne State University

Key Points

  • This research aims to compare weight loss outcomes between GLP-1 receptor agonists and bariatric surgery in adults with obesity.
  • Conducted a systematic review and meta-analysis
  • Included multi-year follow-up data
  • Performed meta-regression analysis
  • Bariatric surgery was associated with greater weight loss compared to GLP-1 receptor agonists
  • Sustained reductions in BMI and glycaemic indices observed over several years
  • Similar effects on serum lipids and blood pressure noted in both interventions

Abstract

Although substantial heterogeneity was present, BS was associated with greater and sustained reductions observed over multi-year follow up in weight, BMI and glycaemic indices compared to GLP-1 RAs, with similar effects on serum lipids and blood pressure, supporting its use in appropriately selected adults with obesity.

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Cite This Study

Tahir et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc98fdc3bde448917fe5https://doi.org/10.1111/dom.70676
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