Adiponectin Inhibits AURKA to Suppress Inflammation in TNF‐α‐induced Keratinocytes and Attenuates Psoriatic Dermatitis in Mice

Key Points

• The research aims to explore how adiponectin influences inflammation and keratinocyte behavior in the context of psoriasis.
• Investigated the effects of adiponectin on TNF-α-induced keratinocytes
• Assessed keratinocyte hyperproliferation and inflammatory markers
• Evaluated the impact of adiponectin on IMQ-induced psoriatic dermatitis in a mouse model
• Adiponectin significantly inhibited keratinocyte hyperproliferation
• Reduced inflammation markers in TNF-α-treated keratinocytes
• APN treatment improved severity of psoriatic dermatitis in mice