Squaratides: A tunable platform for anion binding in peptide inspired macrocycles

Key Points

• The research aims to develop a new class of macrocycles for effective anion binding, integrating squaramide units into peptide-like structures.
• Synthesis of sequence-defined peptidomimetic macrocycles.
• Integration of squaramide units into a peptide backbone.
• Characterization of binding properties with various anions.
• Squaratides show preferential binding for acetate ions.
• Demonstrated tunability in anion binding affinity through structural modification.
• Successful integration of squaramide units enhances macrocycle performance.