Squaratides: A tunable platform for anion binding in peptide inspired macrocycles

Robert B. P. Elmes; Hua Tong; Farhad Ali Mohammed; Chris S. Hawes; Shayon Bhattacharya; Damien Thompson; Katrina A. Jolliffe

doi:10.1039/d6cc00836d

January 1, 2026Chemical CommunicationsOpen Access

Squaratides: A tunable platform for anion binding in peptide inspired macrocycles

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Key Points

The research aims to develop a new class of macrocycles for effective anion binding, integrating squaramide units into peptide-like structures.
Synthesis of sequence-defined peptidomimetic macrocycles.
Integration of squaramide units into a peptide backbone.
Characterization of binding properties with various anions.
Squaratides show preferential binding for acetate ions.
Demonstrated tunability in anion binding affinity through structural modification.
Successful integration of squaramide units enhances macrocycle performance.

Implication

Reveals a new class of macrocycles that bind anions effectively, suggesting a novel approach to receptor design.

Abstract

We report a new class of sequence-defined peptidomimetic macrocycles, termed squaratides, that integrates squaramide units directly into a tunable peptide backbone. These modular receptors exhibit preferential binding of acetate and...

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Cite This Study

Elmes et al. (2026) studied this question.

synapsesocial.com/papers/69c7722a8bbfbc51511e26e8 https://doi.org/10.1039/d6cc00836d

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Squaratides: A tunable platform for anion binding in peptide inspired macrocycles

Key Points

Implication

Abstract

Discussion

Cite This Study

Squaratides: A tunable platform for anion binding in peptide inspired macrocycles

Key Points

Implication

Abstract

Discussion

Cite This Study

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