What question did this study set out to answer?

The research aims to evaluate the effectiveness of various drug classes with distinct antitumor mechanisms against established tumors.

April 1, 2026

Antitumor Activity of Drugs of Various Mechanisms of Action against Advanced Experimental Tumors

Key Points

The research aims to evaluate the effectiveness of various drug classes with distinct antitumor mechanisms against established tumors.
Studied multiple classes of compounds on solid tumor models.
Used drugs such as noble metals, dinitrosyl iron complexes, and nitrosoalkilureas.
Investigated tumor models including human melanoma and various mouse cancers.
Monitored tumor mass and timing of drug administration.
Achieved significant antitumor effects even with late initiation of treatment.
Tumor masses ranged from 120 to 420 mg at the start of drug exposure.
Demonstrated that treatment can be effective on already formed tumors.

Abstract

The effectiveness of drugs with various mechanisms of antitumor action, representing the following classes of compounds, has been studied on the formed solid tumor: noble metals polyacrylate (aurumacryl, argacryl), binuclear dinitrosyl iron complexes (B-DNIC-cysteine), nitrosoalkilureas (methynur, dimethynur, chlonizol, nimustin). The range of tumor models included xenographs of human melanoma BRO, the first generation of spontaneous breast cancer in mice, Lewis lung carcinoma, adenocarcinoma Ca-755, melanoma B-16, leukemia P-388 (solid form). The mass of tumors when exposed to the drugs varied from 120 to 420 mg, and the time to start using the drugs ranged from 5 to 12 days of tumor growth. It is shown that it is possible in principle to achieve a very high antitumor effect with late initiation of treatment and at the effect of drugs on already formed tumors.

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Antitumor Activity of Drugs of Various Mechanisms of Action against Advanced Experimental Tumors

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Abstract

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