Glymphatic dysfunction couples with cortical excitation–inhibition imbalance in epilepsy: Evidence from Rasmussen encephalitis

Key Points

• This research examines the relationship between glymphatic dysfunction and cortical activity in epilepsy, particularly in Rasmussen encephalitis.
• Analyzed glymphatic function through imaging techniques.
• Assessed cortical activity through electrophysiological measurements.
• Explored correlations between perivascular clearance and cortical excitability.
• Found a significant link between glymphatic dysfunction and altered cortical excitability.
• Impaired perivascular clearance correlated with increased inhibitory tones.
• Identified focal atrophy associated with disrupted glymphatic function.