The human spleen likely serves as an important reservoir for monocytes that accumulate in the myocardium following acute myocardial infarction.
Overall, this study showed a unique spatiotemporal pattern of monocyte accumulation in the human myocardium following AMI that coincides with a marked depletion of monocytes from the spleen, suggesting that the human spleen contains an important reservoir function for monocytes.
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European Heart Journal
Harvard University
Massachusetts General Hospital
University of Amsterdam
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Laan et al. (Wed,) studied this question.