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August 21, 2013European Heart JournalOpen Access

There is a unique spatiotemporal pattern of monocyte accumulation in the human myocardium following AMI that coincides with a marked depletion of monocytes from the spleen.

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Population

Humans following acute myocardial infarction (AMI)

Design

Other

Authors

ALAnja M. van der LaanEHE HorstRDRonak Delewi

Discussion

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Overview

Findings on post-AMI monocyte trafficking are hypothesis-generating; should not yet influence clinical practice.

Structured PICO

P
Population
Humans following acute myocardial infarction (AMI)
O
Outcome
Spatiotemporal pattern of monocyte accumulation in the myocardium and depletion in the spleensurrogate

The human spleen likely serves as an important reservoir for monocytes that accumulate in the myocardium following acute myocardial infarction.

Cite This Study

Laan et al. (2013) studied this question.

synapsesocial.com/papers/69d4c4d38cd4b240c8583ebahttps://doi.org/10.1093/eurheartj/eht331
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