What does this research mean for the field?

Elevated peak levels of circulating CD14(+)CD16(-) monocytes after acute myocardial infarction are negatively associated with myocardial salvage and long-term recovery of left ventricular ejection fraction. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether distinct circulating monocyte subsets differentially affect myocardial salvage and functional left ventricular recovery following acute myocardial infarction.

September 26, 2026Journal of the American College of CardiologyOpen Access

Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Primary acute myocardial infarction (n=36). Intervention: CD14(+)CD16(-) and CD14(+)CD16(+) monocyte subsets. Primary outcome: Extent of myocardial salvage at 7 days and recovery of left ventricular ejection fraction at 6 months.

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Key result

Higher day 3 CD14+CD16- monocytes linked to worse myocardial salvage and 6-month LVEF recovery.

n=36

Why the study?

Distinct monocyte subsets in human peripheral blood may contribute differently to myocardial salvage in patients with acute myocardial infarction.

Population

36 patients with primary acute myocardial infarction

Comparison

CD14(+)CD16(-) monocytes vs CD14(+)CD16(+) monocytes

Design

Observational study with serial peripheral blood sampling and cardiovascular magnetic resonance imaging

Follow-up

6 months

Authors

HTHiroto TsujiokaKawasaki Medical School TIToshio ImanishiInterventional / Structural Cardiology HIHideyuki IkejimaUniversity of Modena and Reggio Emilia

Discussion

Member takes

Implication

Observational study reveals elevated CD14+CD16- monocytes hinder myocardial salvage in acute myocardial infarction patients, suggesting targetable pathways for ischemic recovery.

Key Points

To determine whether distinct circulating monocyte subsets differentially affect myocardial salvage and functional left ventricular recovery following acute myocardial infarction.
Enrolled 36 patients with primary acute myocardial infarction.
Quantified CD14(+)CD16(-) and CD14(+)CD16(+) monocyte subsets using flow cytometry on days 1, 2, 3, 4, 5, 8, and 12 post-infarction.
Evaluated myocardial salvage at 7 days and left ventricular ejection fraction at 6 months via cardiovascular magnetic resonance imaging.
Circulating CD14(+)CD16(-) and CD14(+)CD16(+) monocytes peaked at day 3 and day 5 after onset, respectively.
Peak levels of CD14(+)CD16(-) monocytes, but not CD14(+)CD16(+) monocytes, were significantly negatively associated with the extent of myocardial salvage.
Peak CD14(+)CD16(-) monocyte counts were significantly negatively correlated with left ventricular ejection fraction recovery at 6-month follow-up.

Study Design

Type

Observational (n=36)

PICO

Population

36 patients with primary acute myocardial infarction evaluated for monocyte subsets and followed for 6 months.

Exposure / Comparator

CD14(+)CD16(-) and CD14(+)CD16(+) monocyte subsets

Primary Outcome

Extent of myocardial salvage at 7 days and recovery of left ventricular ejection fraction at 6 months

Cite This Study

Tsujioka et al. (2009) conducted an observational in Primary acute myocardial infarction (n=36). CD14(+)CD16(-) and CD14(+)CD16(+) monocyte subsets was evaluated on Extent of myocardial salvage at 7 days and recovery of left ventricular ejection fraction at 6 months. Peak levels of CD14(+)CD16(-) monocytes on day 3 were significantly negatively associated with the extent of myocardial salvage at 7 days and recovery of left ventricular function at 6 months.

synapsesocial.com/papers/6ab7e1b3b0b7d0eae2e837b7 https://doi.org/10.1016/j.jacc.2009.04.021

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Implication

Observational study reveals elevated CD14+CD16- monocytes hinder myocardial salvage in acute myocardial infarction patients, suggesting targetable pathways for ischemic recovery.

Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Also Consider

Also Consider