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May 2, 2014Circulation ResearchOpen Access

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

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Population

Preclinical model studying heart macrophages during steady state, after macrophage depletion, and in…

Design

Preclinical

Authors

THTimo HeidtCardiac ImagingGCGabriel CourtiesHeart Failure & TransplantPDPartha DuttaUniversity of Pittsburgh

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Implication

Should not yet inform clinical care; extends animal data on monocyte dynamics in post-MI cardiac immunosurveillance.

Structured PICO

P
Population
Preclinical model studying heart macrophages during steady state, after macrophage depletion, and in acute/chronic phases post-myocardial infarction
O
Outcome
Contribution of monocytes to heart macrophages and their role in immunosurveillance

This study highlights the dynamic contribution of monocytes to heart macrophages and their role in myocardial immunosurveillance during steady state and after myocardial infarction.

Cite This Study

Heidt et al. (2014) studied this question.

synapsesocial.com/papers/69d3e5e166126558fa4ce3cfhttps://doi.org/10.1161/circresaha.115.303567

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions2007 · 2,326 citations
  2. 2Distribution of myocardial macrophages in the normal human heart1997 · 36 citations
  3. 3Monocyte and Macrophage Heterogeneity in the Heart2013 · 372 citations
  4. 4Infective Endocarditis in Adults2001 · 1,333 citations
  5. 5Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure2013 · 350 citations